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Prof Paul De Souza

Head, Medical Oncology Group

Our group has many varied interests in cancer research. These range from basic science to translational cancer research to clinical research. Cancers of interest for the group include colorectal, prostate, breast, ovarian, brain, gastric, melanoma, lung cancer. We have a range of cutting edge technologies ranging from the IncuCyte to digital droplet PCR to circulating tumour cell assays and flow cytometry. Our work involves trying to find the causes of some cancers, the mechanism of action of various drugs, biomarkers and novel drug discovery. We are especially interested in translational cancer research, which links basic scientists to clinical doctors in a very practical way to promote and generate research that answers important clinical questions, yet continues to stretch the boundaries of clinical work with new and important research questions.

Fields of research

  • Oncology and Carcinogenesis

Publications

C1 - Journal Article

E1 - Conference Abstract

  • Basch EM, Sholz MC, De Bono JS, Vogelzang NJ, De Souza PL, Marx GM, Vaishampayan UN, George S, Schwarz JK, Antonarakis ES, O'Sullivan JM, Kelabasty AR, Chi KN, Dreicer R, Hutson TE, Mangeshkar M, Holland JS, Weitzman A, Scher HI 2015, Final analysis COMET-2: Cabozantinib (Cabo) versus mitoxantrone/prednisone (MP) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) with moderate to severe pain who were previously treated with docetaxel(D) and abiraterone (A) and/or enzalutamide (E), Genitourinary Cancers Symposium, AMER SOC CLINICAL ONCOLOGY, vol. 33, no. 7
  • Lim SH, Ng W, Chua W, Descallar J, Spring K, De Souza P 2015, Psychological parameters and circulating tumor cells in locally advanced rectal cancer, WILEY-BLACKWELL, vol. 11, p. 57
  • De Souza P, Smith MR, Fizazi K, Saad F, Mulders PFA, Sternberg CN, Miller K, Logothetis CJ, Shore N, Small EJ, Carles J, Flaig TW, Taplin M-E, Higano CS, De Bono JS, Griffin TW, De Porre P, Yu MK, Park YC, Li J, Kheoh T, Naini V, Molina A, Rathkopf DE, Ryan CJ 2015, Final analysis of the randomised, phase 3, COU-AA-302 study of abiraterone acetate (AA) in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (mCRPC), 68th Annual Scientific Meeting of the Urological-Society-of-Australia-and-New Zealand, WILEY-BLACKWELL, vol. 115, pp. 21-22
  • Lim S, Ng W, Chua W, Descallar J, Spring K, De Souza P 2015, Quality of life and circulating tumour cells in patients treated with neoadjuvant chemoradiation for rectal cancer - is there a link?, European Cancer Congress, ELSEVIER SCI LTD, vol. 51, p. S224
  • Lim S, Chua W, Ng W, Descallar J, Bokey L, Spring K, De Souza P 2015, Presence of circulating tumour cells and correlation with inflammatory markers in non-metastatic rectal cancer, European Cancer Congress, ELSEVIER SCI LTD, vol. 51, p. S391

Grants

  • 2017 Biosceptre - Drug development - Extension 1 Paul de Souza; Biosceptre (Aust) Limited.
  • 2017 Noxopharm_Drug development Paul de Souza; Noxopharm Limited.
  • 2016 Centre for Oncology Education and Research Translation (CONCERT) [via UNSW] Paul de Souza, Michael Barton, Soon Lee, Afaf Girgis, Geoff Delaney, Leslie Bokey, Marie Ranson; South Western Sydney Local Health District (SWSLHD).
  • 2016 New field emission scanning electron microscopy (FESEM) facility De Souza, PL*; NSW Health Pathology.
  • 2016 cultural biographies, medical knowledges: a sociological study ; ROYAL BRISBANE AND WOMEN'S HOSPITAL FOUNDATION.
  • 2016 cultural biographies, medical knowledges: a sociological study ; University of Technology Sydney (UTS).
  • 2016 cultural biographies, medical knowledges: a sociological study ; Monash University.
  • 2016 cultural biographies, medical knowledges: a sociological study ; South Western Sydney Local Health District (SWSLHD).
  • 2016 cultural biographies, medical knowledges: a sociological study ; South Eastern Sydney Local Health District (SESLHD).
  • 2016 cultural biographies, medical knowledges: a sociological study ; METRO NORTH HOSPITAL AND HEALTH SERVICE.
  • 2016 cultural biographies, medical knowledges: a sociological study ; AUSTRALIAN RESEARCH COUNCIL.
  • 2016 Atridia_Assays for circulating tumour cells, ARV7 and PARP Paul de Souza, Therese Becker, Kieran Scott; Atridia Pty Ltd.
  • 2016 Biosceptre_Drug development Paul de Souza; Biosceptre (Aust) Limited.
  • 2016 superresolution light microscope for deep view functional analyses of cancer cells and their microenvironment: a springboard and partner technology for high resolution correlative microscopy studies in cancer research. ; University of New South Wales (UNSW).
  • 2015 Scholarship Proposal for Dr Stephanie Lim De Souza, PL*; Spring, K; Ng, WL*; Chua, W*; South Western Sydney Local Health District (SWSLHD).
  • 2015 Cryogenic Correlative Light And Immunoelectron Microscopy Using Field Emission Scanning Electron Microscopy (FESEM) A New Way To Look At Cancer And Its Microenvironment. De Souza, PL*; Killingsworth, M*; Apte, MV*; Ranson, M; Scott, RJ^; Price, WS^; Bobryshev, YV^; Packer, NH; Valenzuela, S; Cancer Institute NSW.
  • 2014 Centre for Oncology Education and Research Translation (CONCERT) [via UNSW] Paul de Souza, Michael Barton, Soon Lee, Afaf Girgis, Geoff Delaney, Leslie Bokey, Marie Ranson; Cancer Institute NSW.
  • 2014 A translational and pharmacokinetic study of a novel, orally-active, targeted treatment for hormone refractory prostate cancer Paul de Souza, Kieran Scott, Winston Liauw, Garry Graham, Paul Young, Pamela Russell; Prostate Cancer Foundation of Australia.
  • 2014 Centre for Oncology Education and Research Translation (CONCERT) De Souza, PL*; Barton, MB*; Lee, S; Girgis, A*; Delaney, GP*; Bokey, L; Ranson, M; Kienzle, N*; Jones, G; Cancer Institute NSW.
  • 2014 Biology of circulating tumour cells in patients with advanced ovarian cancer: Does epithelial to mesenchymal transition (EMT) contribute to chemoresistance? Paul de Souza, Therese Becker, Anna de Fazio; South Western Sydney Local Health District (SWSLHD).
  • 2014 Biology of circulating tumour cells in patients with advanced ovarian cancer: Does epithelial to mesenchymal transition (EMT) contribute to chemoresistance? Paul de Souza, Therese Becker, Anna de Fazio; Australian Rotary Health (non ACRG).
  • 2014 An automated micromanipulator platform to capture viable single cells for culture and molecular analyses Paul de Souza, Therese Becker, Kevin Spring; Cancer Institute NSW.
  • 2014 Centre for Oncology Education and Research Translation (CONCERT) [via UNSW] Paul de Souza, Michael Barton, Soon Lee, Afaf Girgis, Geoff Delaney, Leslie Bokey, Marie Ranson; Western Sydney University (WSU).
  • 2013 Veridex "CellSearch" machine for detection of circulating tumour cells Paul de Souza, Pamela Russell, Kieran Scott; Prostate Cancer Foundation of Australia.
  • 2012 South West Sydney Translational Cancer Research Unit [via Ingham Institute for Applied Medical Research] Paul de Souza, Soon Lee, Leslie Bokey; Cancer Institute NSW.
  • 2010 Preclinical evaluation of novel prostate-targeted nanoparticles for imaging primary and metastatic prostate cancer Khatri, A^; Thierry, B; Walsh, B^; Bucci, J*; De Souza, PL*; Cancer Australia.
  • 2010 Anti-Mitochondrial Cancer Drugs Hogg, P*; Ward, RL*; Dawes, IW*; Lock, RB*; De Souza, PL*; Cancer Institute NSW.
  • 2010 A Translational & Pharmacokinetic study of a Novel, Orally-active, Targeted Treatment for Hormone Refractory Prostate Cancer De Souza, PL*; Prostate Cancer Foundation of Australia.